Research has suggested that BPC-157 may have research relevancy; thus, guidance on this front is important. Here are a few of the hypothesized properties suggested by research studies:
- Accelerating the healing process after injury.
- Promoting the recovery of wounds.
- Reducing intestinal inflammation.
Research suggests that BPC-157 may revolutionize how scientists approach injuries.
BPC-157 Peptide: What is it?
“Body Protection Compound” (abbreviated as “BPC”) is a synthetic peptide of fifteen amino acids. Endogenous BPC is the source of BPC-157. In 1991, scientists found this peptide in stomach fluids; subsequently, they isolated it to study its potential within gastrointestinal research. Researchers speculated several other possible applications for BPC-157 after originally examining the chemical in the context of stomach ulcers. More specifically, BPC-157 has been hypothesized to have the potential to aid in the healing process for research models.
There is speculation that BPC 157 may speed up recovery from wounds in the skin, muscles, tendons, ligaments, and bones. In addition, following a serious injury that did not heal on its own, there appeared to be a significant improvement in the skin wound and the muscles, tendons, ligaments, and bones. These stages of healing raise the possibility that BPC 157 may have a unique potential on tissue repair.
BPC-157 Peptide: Mechanism of Action
When tested on research models, BPC-157 is thought to have several ways of promoting healing properties. A key step, known as angiogenesis, is the creation of new blood vessels. To do this, BPC-157 has been theorized to increase vascular endothelial growth factor (VEGF) levels, a protein that promotes the evolution of new blood vessels in the organism. Investigations purport it may boost the organism’s ability to pump blood by boosting NO production and release. BPC-157 seems to be a peptide that might enhance physical activity, albeit not in the manner that scientists would expect.
Research on animals has purported that BPC-157 may hasten the healing process after several injuries. BPC-157 peptide is still considered a research chemical for the time being. In terms of BPC-157’s positive impacts on general physiological function, what does the research say?
BPC-157 Peptide Potential
It should be noted that the properties of BPC-157 are only speculations. Research using this chemical has mostly used cell cultures and experimental animals. Researchers are the only ones who may purchase BPC-157 from Biotech Peptides as it has not yet passed a clinical study. This is a quick rundown of what we know about BPC-157 from previous investigations.
BPC-157 Peptide and the Brain
The link between rat gut function and cognitive problems was the subject of a 2016 BPC-157 systematic review. According to their findings, BPC-157 appeared to have the following impacts on the brain function of the rats:
- Rats subjected to continuous and unexpected stress showed a significant reduction in depression.
- Reduction of alcohol intoxication and withdrawal symptoms.
- The brain’s injured nerve branches were repaired.
Researchers are quite interested in BPC-157 because, among other things, it seems to be stable in stomach juice.
BPC-157 Peptide and Traumatic Brain Injury (TBI)
Researchers hypothesized that BPC-157 may effectively aid mice’s traumatic brain injury (TBI). In a 2010 research study, mice with brain injuries were given BPC-157. Unlike the placebo group, the BPC-157 group with the highest concentration outlived the control group. In addition, compared to the placebo group, the rats given BPC-157 seemed to have far less damage 24 hours after the injury.
BPC-157 Peptide and the Gut
BPC-157 has been suggested to affect gut function in several ways. It is implied it may prevent inflammatory bowel disease (IBD) problems, reduce gut inflammation (both acute and chronic), and correct short-bowel syndrome after intestinal resection. Findings imply that in addition to possibly preventing ulcers from forming, BPC-157 may also reverse intestinal damage.
BPC-157 Peptide and Induced Toxicity
BPC-157 may potentially mitigate or counteract the harmful effects of supplemental compounds. Take, for example, the potentially lethal effects of excessive amounts of nonsteroidal anti-inflammatory compounds (NSAIDs). Symptoms of toxicity include low blood pressure, respiratory depression, and convulsions.
Researchers theorized in 2013 that BPC-157 might mitigate the negative effects of nonsteroidal anti-inflammatory compounds (NSAIDs). In a rat study, researchers indicated that BPC-157 might have mitigated the neurotoxicity caused by methamphetamine, which is consistent with previous insights.
BPC-157 Peptide and Inflammation
According to a trial involving rats with periodontitis (an infection of the gums accompanied by severe inflammation), rats given BPC-157 in 2009 did not seem to experience a decline in blood circulation. Of utmost importance, BPC-157 suggested anti-inflammatory properties while simultaneously promoting gum tissue repair and preservation.
Please note that you cannot generalize the findings from the animal above research to people. Still, these results could be useful for researchers planning future BPC-157 trials on animals. Only licensed professionals are allowed to acquire and utilize peptide compounds.
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References
[i] Sikiric P, Hahm KB, Blagaic AB, Tvrdeic A, Pavlov KH, et al. Stable Gastric Pentadecapeptide BPC 157, Robert’s Stomach
[ii] Brcic L, Brcic I, Staresinic M, Novinscak T, Sikiric P, et al. Modulatory effect of gastric pentadecapeptide BPC 157 on angiogenesis in muscle and tendon healing. J Physiol Pharmacol. 2009;60 Suppl 7:191-6.
[iii] Grabarevic Z, Tisljar M, Artukovic B, Bratulic M, Dzaja P, et al. The influence of BPC 157 on nitric oxide agonist and antagonist induced lesions in broiler chicks. J Physiol Paris. 1997 May-Oct;91(3- 5):139-49.
[iv] Sikiric P, Seiwerth S, Rucman R, et al. Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications. Curr Neuropharmacol. 2016;14(8):857–865. doi:10.2174/1570159×13666160502153022.
[v] Tudor M, Jandric I, Marovic A, Gjurasin M, Perovic D, et al. Traumatic brain injury in mice and pentadecapeptide BPC 157 effect. Regul Pept. 2010;160(1-3):26-32. doi: 10.1016/j.regpep.2009.11.012.
[vi] Sikiric P, Sikiric PS, Seiwerth S, Rucman R, Turkovic B, et al. Effect of Pentadecapeptide BPC 157 on Gastrointestinal Tract. Front Gastrointest Res. 2010;30:191-201. doi:10.1159/000338435.
[vii] Sikiric P, Seiwerth S, Rucman R, Turkovic B, Rokotov DS, et al. Toxicity by NSAIDs. Counteraction by stable gastric pentadecapeptide BPC 157. Curr Pharm Des. 2013;19(1):76-83.[viii] Suran J, Kolenc D, Crnic AP, Radic B, Drmic I, et al. The effect of pentadecapeptide BPC 157 in metamphetamine-induced dopaminergic neurotoxicity (1143.11). FASEB J. 2014;28:Suppl1.